Scientific Evidence

A comprehensive body of scientific evidence on natural substances developed by Aboca.

  • Preclinical Studies

    Author

    Veronica Cocchi , Sofia Gasperini and Monia Lenzi

    Title

    Anthraquinones: Genotoxic until Proven Otherwise? A Study on a Substance-Based Medical Device to Implement Available Data for a Correct Risk Assessment
    DOI https://doi.org/10.3390/toxics10030142

    Abstract

    A genotoxicological study was carried out on a substance-based medical device (SMD) containing anthraquinones in order to evaluate its potential mutagenic effect. The “In Vitro Mammalian Cell Micronucleus Test” was performed on human TK6 cells by flow cytometry. Cultures were treated with concentrations of SMD tested in the range of 0–2 mg/mL for short treatment time (3 h)… Read more

    Year

    2022
  • Preclinical Studies

    Author

    Greco CM, Garetto S, Montellier E, Liu Y, Chen S, Baldi P, Sassone-Corsi P, Lucci J.

    Title

    A non-pharmacological therapeutic approach in the gut triggers distal metabolic rewiring capable of ameliorating diet-induced dysfunctions encompassed by metabolic syndrome
    DOI https://doi.org/10.1038/s41598-020-69469-y

    Abstract

    Metabolic syndrome has increased at a worrisome level. Lifestyle changes are not sufficient to prevent and improve the adverse effects of obesity, thus novel interventions are necessary. The aim of this study was to investigate the use and metabolic outcomes of a non-pharmacological intervention in a high-fat diet (HFD) fed mouse model, capable of recapitulating key aspects of metabolic… Read more

    Year

    2020
    Products: Metarecod* - Libramed*
    Public Link
  • Preclinical Studies

    Author

    Parisio C, Lucarini E, Micheli L, Toti A, Di Cesare Mannelli L, Antonini G, Panizzi E, Maidecchi A, Giovagnoni E, Lucci J, Ghelardini C.

    Title

    Researching New Therapeutic Approaches for Abdominal Visceral Pain Treatment: Preclinical Effects of an Assembled System of Molecules of Vegetal Origin
    DOI https://doi.org/10.3390/nu12010022

    Abstract

    Abdominal pain is a frequent symptom of irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBDs). Although the knowledge of these pathologies is progressing, new therapeutic strategies continue to be investigated. In the present study, the effect of a system of molecules of natural origin (a medical device according to EU Directive 93/42/EC, engineered starting from Boswellia… Read more

    Year

    2019
    Products: Colilen IBS
    Public Link
  • Preclinical Studies

    Author

    G. Liguori, F. Baldi, M.P. Di Simone

    Title

    Topical protection of esophageal mucosa: in vitro evaluation of the protective effect of a medical device made of natural substances in comparison with sodium alginate

    Abstract

    OBJECTIVES: The integrity of the esophageal mucosal barrier is the first mechanism of protection against gastro-esophageal reflux. A possible strengthening action of esophageal mucosal barrier could be given by topical agents that act by reducing its permeability. Our aim was to test the protective effect of a medical device made of substances (MDMS), composed by natural complex (… Read more

    Year

    2018
    Products: Neobianacid
    On demand
  • Preclinical Studies

    Author

    Valerio Ciccone, Martina Monti, Giulia Antonini, Luisa Mattoli, Michela Burico, Francesca Marini, Anna Maidecchi e Lucia Morbidelli

    Title

    Efficacy of AdipoDren ® in Reducing Interleukin-1-Induced Lymphatic Endothelial Hyperpermeability
    DOI https://doi.org/10.1159/000452798

    Abstract

    Lymphatic leakage can be seen as a detrimental phenomenon associated with fluid retention and deposition as well as gain of weight. Moreover, lymphatic dysfunction is associated with an inflammatory environment and can be a substrate for other health conditions. A number of treatments can ameliorate lymphatic vasculature: natural substances have been used as treatment options particularly… Read more

    Year

    2016
    Products: Lynfase
    Public Link