Scientific Evidence

A comprehensive body of scientific evidence on natural substances developed by Aboca.

  • Clinical Studies

    Author

    Corazziari Enrico Stefano; Gasbarrini Antonio; D'Alba Lucia; D'Ovidio Valeria; Riggio Oliviero; Passaretti Sandro; Annibale Bruno; Cicala Michele; Repici Alessandro; Bassotti Gabrio; Ciacci, Carolina; Di Sabatino Antonio; Neri Matteo; Bragazzi Maria Consiglia; Ribichini Emanuela; Radocchia Giulia; Iovino Paola; Marazzato Massimiliano; Schippa Serena; Badiali Danilo

    Title

    Poliprotect vs Omeprazole in the Relief of Heartburn, Epigastric Pain, and Burning in Patients Without Erosive Esophagitis and Gastroduodenal Lesions: A Randomized, Controlled Trial
    DOI 10.14309/ajg.0000000000002360

    Abstract

    INTRODUCTION: In the treatment of upper GI endoscopy-negative patients with heartburn and epigastric pain or burning, antacids, antireflux agents, and mucosal protective agents are widely used, alone or as add-on treatment, to increase response to proton-pump inhibitors, which are not indicated in infancy and pregnancy and account for significant cost expenditure.

    METHODS: In this… Read more

    Year

    2023
    Products: Neobianacid
    Public Link
  • Clinical Studies

    Author

    Giorgia Centorame, Maria Pompea Antonia Baldassarre, Giulia Di Dalmazi, Francesca Gambacorta, Fabrizio Febo, Agostino Consoli, Gloria Formoso

    Title

    Policaptil Gel Retard® reduces body weight and improves insulin sensitivity in obese subjects
    DOI https://doi.org/10.15586/ijfs.v34i2.2204

    Abstract

    Policaptil Gel Retard® (PGR), a natural fiber-based molecule, has been shown to prevent weight gain and ameliorate insulin-resistance indices in obese children and adolescents. The aim of this study was to compare the effects of 12 weeks of low calories and low glycemic index (LC-LGI) diet associated or not with the intake of PGR on anthropometric, bioimpedance, and metabolic parameters. Data… Read more

    Year

    2022
    Products: Metarecod* - Libramed*
    Public Link
  • Clinical Studies

    Author

    Giuseppina Guarino, Felice Strollo, Peter Malfertheiner, Teresa Della Corte, Stefano Stagi, Mario Masarone, Sandro Gentile

    Title

    Efficacy and safety of a polysaccharide-based natural substance complex in the treatment of Obesity and other Metabolic Syndrome components: a systematic review
    DOI https://doi.org/10.3389/fdsfr.2022.844256

    Abstract

    Introduction: Metabolic syndrome (MetS) is increasingly common in adults as well as in children and adolescents. However, preventing and treating MetS is one of the most pressing challenges for public health services worldwide. At present, the only approved treatments for MetS are dietary changes and physical activity, which are associated with a high rate of non-compliance.… Read more

    Year

    2022
    Products: Metarecod* - Libramed*
    Public Link
  • Clinical Studies

    Author

    Giuseppina Guarino, Felice Strollo, Teresa Della-Corte, Ersilia Satta, Carmine Romano, Carmelo Alfarone, Gerardo Corigliano, Marco Corigliano, Giuseppe Cozzolino, Clementina Brancario, Carmine Martino, Domenica Oliva, Agostino Vecchiato, Clelia Lamberti, Luca Franco and Sandro Gentile

    Title

    Comparison between Policaptil Gel Retard and Metformin by Testing of Temporal Changes in Patients with Metabolic Syndrome and Type 2 Diabetes
    DOI https://doi.org/10.3390/diabetology3020022

    Abstract

    Introduction: Metabolic Syndrome (MS) is a pathologic condition characterized by Type 2 diabetes mellitus (T2DM), insulin resistance, abdominal obesity, hypertension, and hyperlipidemia. Until now, specific drugs such as metformin (MET) have been used to address its individual components; however, according to the recommendation of WHO, various plant extracts might be used as… Read more

    Year

    2022
    Products: Metarecod* - Libramed*
    Public Link
  • Clinical Studies

    Author

    Stefano Stagi, Valeria Papacciuoli, Daniele Ciofi, Barbara Piccini , Giovanni Farello, Sonia Toni, Marta Ferrari and Francesco Chiarelli

    Title

    Retrospective Evaluation on the Use of a New Polysaccharide Complex in Managing Paediatric Type 1 Diabetes with Metabolic Syndrome (MetS)

    Abstract

    Background: Children and adolescents affected by type 1 diabetes have an increased risk of being overweight or obese and of suffering from cardiometabolic symptoms. Aims: To retrospectively evaluate the effects of a new complex of polysaccharide macromolecules, Policaptil Gel Retard® (PGR), on auxological and metabolic parameters, glycaemic variability and control… Read more

    Year

    2021
    Products: Metarecod*- Libramed*
    Public Link
  • Clinical Studies

    Author

    Podda Mariangela, Laureti Silvio, Gentilini Lorenzo, Vittori Laura, Poggioli Gilberto

    Title

    Prospective Interventional Study to Evaluate the Effect of a Medical Device Made of Substances in Reducing Signs and Symptoms in Patients with Hemorrhoidal Disease
    DOI 10.36648/2386-5180.9.4.345

    Abstract

    Background and Aim: Hemorrhoidal Disease (HD) is a chronic pathology and is fairly common in the general population. For this reason, conservative therapies need to be at the same time effective and tolerated. The topical medications available usually contain either a combination of local anesthetics with anti-inflammatories or muscle relaxants, thus addressing a single… Read more

    Year

    2021
    Products: Neofitoroid BioOintment
    Public Link
  • Clinical Studies

    Author

    Caterina Strisciuglio, Vincenzo Coppola, Marina Russo, Carlo Tolone, Gian Luigi Marseglia, Alberto Verrotti, Silvia Caimmi, Claudia Caloisi, Valeria D’Argenio, Lucia Sacchetti and Annamaria Staiano

    Title

    Promelaxin Microenemas Are Non-inferior to Oral Polyethylene Glycol for the Treatment of Functional Constipation in Young Children: A Randomized Clinical Trial
    DOI https://doi.org/10.3389/fped.2021.753938

    Abstract

    Background: Polyethylene glycol (PEG) is recommended as first-line treatment of pediatric functional constipation. However, the oral route of administration is often poorly feasible in children mostly due to poor palatability. Promelaxin microenemas exert a topical evacuative action and may offer a valuable option in pediatric FC.
    Aim: To assess whether… Read more

    Year

    2021
    Products: Melilax Pediatric
    Public Link
  • Clinical Studies

    Author

    Guarino G., Della Corte T., Strollo F., Gentile S.

    Title

    Policaptil Gel Retard in adult subjects with the metabolic syndrome: Efficacy, safety, and tolerability compared to metformin
    DOI https://doi.org/10.1016/j.dsx.2021.03.032

    Abstract

    Background: Policaptil Gel Retard® (PGR), is a new macromolecule complex based on polysaccharides slowing the rate of carbohydrate and fat absorption. It proved to significantly reduce body weight, acanthosis nigricans expression, HbA1c levels, and glucose metabolism abnormalities in obese, hyper-insulinemic adolescents. No such data are available for adults. Aim: to compare… Read more

    Year

    2021
    Products: Metarecod* - Libramed*
    Public Link
  • Clinical Studies

    Author

    Vitalia Murgia, Sara Manti, Amelia Licari, Maria De Filippo, Giorgio Ciprandi e Gian Luigi Marseglia

    Title

    Upper Respiratory Tract Infection-Associated Acute Cough and the Urge to Cough: New Insights for Clinical Practice
    DOI https://doi.org/10.1089/ped.2019.1135

    Abstract

    Upper respiratory tract infection (URTI)-associated acute cough is the most common symptom both in children and adults worldwide and causes economic and social problems with significant implications for the patient, the patient's family, and the health care system. New pathogenic mechanisms in acute cough, including the urge to cough (UTC) mechanisms, have been recently identified. The… Read more

    Year

    2020
    Products: Grintuss Pediatric
    On demand
  • Clinical Studies

    Author

    Elena Fornari , Anita Morandi, Claudia Piona, Mara Tommasi, Massimiliano Corradi and Claudio Maffeis

    Title

    Policaptil Gel Retard Intake Reduces Postprandial Triglycerides, Ghrelin and Appetite in Obese Children: A Clinical Trial
    DOI 10.1186/s13052-018-0497-6

    Abstract

    The aim of this study is to test the hypothesis that the intake of Policaptil Gel Retard® (PGR) is able to affect appetite, metabolic and hormonal postprandial profile in obese children. 46 obese children were randomly assigned to treatment with PGR or placebo, in a double blind clinical trial. Two PGR tablets or placebo were given in fasting condition, before the ingestion of a mixed meal (15… Read more

    Year

    2020
    Products: Metarecod* - Libramed*
    Public Link