Scientific Evidence

A comprehensive body of scientific evidence on natural substances developed by Aboca.

  • Biodegradability

    Author

    Luisa Mattoli, Giacomo Proietti, Claudio Marzio Quintiero, Giada Fodaroni, Michela Burico, Mattia Gianni, Emiliano Giovagnoni, Valentino Mercati and Claudio Santi

    Title

    New insight into the evaluation of Complex Mixtures Biodegradability. UHPLC-qToF “all-ion MS/MS” acquisition technique for the Untargeted and Targeted Analysis of Pharmaceutical Formulations Biodegradation
    DOI https://doi.org/10.1039/D1VA00038A

    Abstract

    UHPLC-qToF analysis is reported here as a modern and reliable spectrometric technique, for a more accurate evaluation of the biodegradation of pharmaceutical formulations that should be considered as complex mixtures of organic compounds interacting with naturally occurring microfauna. The untargeted approach evidences that natural and non-natural compounds are not equally biodegraded even… Read more

    Year

    2022
    Products: Grintuss Pediatric
    Public Link
  • Clinical Studies

    Author

    Vitalia Murgia, Sara Manti, Amelia Licari, Maria De Filippo, Giorgio Ciprandi e Gian Luigi Marseglia

    Title

    Upper Respiratory Tract Infection-Associated Acute Cough and the Urge to Cough: New Insights for Clinical Practice
    DOI https://doi.org/10.1089/ped.2019.1135

    Abstract

    Upper respiratory tract infection (URTI)-associated acute cough is the most common symptom both in children and adults worldwide and causes economic and social problems with significant implications for the patient, the patient's family, and the health care system. New pathogenic mechanisms in acute cough, including the urge to cough (UTC) mechanisms, have been recently identified. The… Read more

    Year

    2020
    Products: Grintuss Pediatric
    On demand
  • Metabolomics & Analytical Sciences

    Author

    L. Mattoli, M. Burico, G. Fodaroni, S. Tamimi, S. Bedont, P. Traldi, M. Stocchero

    Title

    New frontiers in pharmaceutical analysis: A metabolomic approach tocheck batch compliance of complex products based on natural substances
    DOI https://doi.org/10.1016/j.jpba.2016.04.010

    Abstract

    Natural substances, particularly medicinal plants and their extracts, are still today intended as source for new Active Pharmaceutical Ingredients (APIs). Alternatively they can be validly employed to prepare medicines, food supplements or medical devices. The most adopted analytical approach used to verify quality of natural substances like medicinal plants is based still… Read more

    Year

    2016
    Products: Grintuss Adult
    Public Link
  • Clinical Studies

    Author

    Herman Avner Cohen, Moshe Hoshen, Shmuel Gur, Arie Bahir, Yoseph Laks & Hannah Blau

    Title

    Efficacy and tolerability of a polysaccharide-resin-honey based cough syrup as compared to carbocysteine syrup for children with colds: a randomized, single-blinded, multicenter study
    DOI https://doi.org/10.1007/s12519-016-0048-4

    Abstract

    Background
    Available pediatric treatments for acute cough are limited by lack of demonstrated efficacy. The objective of this trial is to compare the effects of a polysaccharide-resin-honey based cough syrup, and carbocysteine syrups on nocturnal and daytime cough associated with childhood upper respiratory tract infections (URIs).
    Methods
    Read more

    Year

    2016
    Products: Grintuss Pediatric
    On demand
  • Clinical Studies

    Author

    Mario Canciani, Vitalia Murgia, Davide Caimmi, Sreedhar Anapurapu, Amelia Licari e Gian Luigi Marseglia

    Title

    Efficacy of Grintuss® pediatric syrup in treating cough in children: a randomized, multicenter, double blind, placebo-controlled clinical trial
    DOI https://doi.org/10.1186/1824-7288-40-56

    Abstract

    Background
    Cough is an extremely common problem in pediatrics, mostly triggered and perpetuated by inflammatory processes or mechanical irritation leading to viscous mucous production and increased sensitivity of the cough receptors. Protecting the mucosa might be very useful in limiting the contact with micro-organisms and irritants thus decreasing the inflammation and… Read more

    Year

    2014
    Products: Grintuss Pediatric
    Public Link