Scientific Evidence

A comprehensive body of scientific evidence on natural substances developed by Aboca.

  • Metabolomics & Analytical Sciences

    Author

    Michela Burico, Giada Fodaroni, Enrico Flamini, Nicola Ascani, Giacomo Proietti, Sara Tamimi, Claudio Marzio Quintiero, Luca Massa, Mattia Gianni, Luisa Mattoli

    Title

    Metabolomic fingerprint of Hamamelis virginiana L. gallotannins by suspect screening analysis with UHPLC-qToF and their semi-quantitative evaluation
    DOI https://doi.org/10.1002/jms.4878

    Abstract

    The evolution of the regulatory framework for medical devices in the EU (Reg 2017/745) has opened the study of complex systems emerging properties. This makes necessary to identify new analytical approaches able of characterizing com-plex natural substrates as completely as possible. Therefore, omics approaches and advanced analytical methods for the determination of metabolite classes appear… Read more

    Year

    2022
  • Metabolomics & Analytical Sciences

    Author

    Mattoli L, Gianni M, Burico M.

    Title

    Mass spectrometry-based metabolomic analysis as a tool for quality control of natural complex products
    DOI https://doi.org/10.1002/mas.21773

    Abstract

    Metabolomics is an area of intriguing and growing interest. Since the late 1990s, when the first Omic applications appeared to study metabolite's pool (“metabolome”), to understand new aspects of the global regulation of cellular metabolism in biology, there have been many evolutions. Currently, there are many applications in different fields such as clinical, medical,… Read more

    Year

    2022
  • Metabolomics & Analytical Sciences

    Author

    Sara Crotti, Sara D'Aronco, Laura Moracci, Francesco Tisato, Marina Porchia, Luisa Mattoli, Michela Burico, Stella Bedont, Pietro Traldi e Marco Agostini

    Title

    Evidence of noncovalent complexes in some natural extracts: Ceylon tea and mate extracts
    DOI https://doi.org/10.1002/jms.4459

    Abstract

    Considering the high complexity of natural extracts, because of the presence of organic molecules of different chemical nature, the possibility of formation of noncovalent complexes should be taken into account. In a previous investigation, the formation of bimolecular complexes between caffeine and catechins in green tea extracts (GTE) has been experimentally proven by means of mass… Read more

    Year

    2019
  • Metabolomics & Analytical Sciences

    Author

    Luisa Mattoli, Valentino Mercati, Michela Burico, Stella Bedont, Marina Porchia, Francesco Tisato, Sara D’Aronco, Sara Crotti, Marco Agostini e Pietro Traldi

    Title

    Experimental Evidence of the Presence of Bimolecular Caffeine/Catechin Complexes in Green Tea Extracts
    DOI https://doi.org/10.1021/acs.jnatprod.8b00168

    Abstract

    A hypothesis on the peculiar pharmacological behavior of biologically active natural compounds is based on the occurrence of molecular interactions originating from the high complexity of the natural matrix, following the rules of supramolecular chemistry. In this context, some investigations were performed to establish unequivocally the presence of caffeine/catechin complexes in green tea… Read more

    Year

    2018
  • Metabolomics & Analytical Sciences

    Author

    L. Mattoli, M. Burico, G. Fodaroni, S. Tamimi, S. Bedont, P. Traldi, M. Stocchero

    Title

    New frontiers in pharmaceutical analysis: A metabolomic approach tocheck batch compliance of complex products based on natural substances
    DOI https://doi.org/10.1016/j.jpba.2016.04.010

    Abstract

    Natural substances, particularly medicinal plants and their extracts, are still today intended as source for new Active Pharmaceutical Ingredients (APIs). Alternatively they can be validly employed to prepare medicines, food supplements or medical devices. The most adopted analytical approach used to verify quality of natural substances like medicinal plants is based still… Read more

    Year

    2016
    Products: Grintuss Adult
    Public Link
  • Metabolomics & Analytical Sciences

    Author

    Giada Fodaroni, Michela Burico, Anna Gaetano, Anna Maidecchi, Rita Pagiotti, Luisa Mattoli, Pietro Traldi e Eugenio Ragazzi

    Title

    An Integrated Approach to the Evaluation of a Metabolomic Fingerprint for a Phytocomplex. Focus on Artichoke
    DOI https://doi.org/10.1177/1934578X1400900436

    Abstract

    The availability of reliable herbal formulations is essential in order to assure the maximal activity and to limit unwanted side-effects. The correct concentration of declared components of herbal products is a matter of health legislation and regulation, but is still a topic under debate in the field of quality control assessment. In the present work specific constituents of artichoke leaf… Read more

    Year

    2014
  • Metabolomics & Analytical Sciences

    Author

    Luisa Mattoli, Valentino Mercati, Anna Gaetano, Rita Pagiotti, Eugenio Ragazzi, Francesco Tisato e Pietro Traldi

    Title

    A hypothesis on peculiar pharmacological behaviour of biologically active natural compounds

    Abstract

    A hypothesis is presented to explain the bioactivity of natural extracts, often higher than that of the synthetic bioactive components. This view is different from that based on synergy of the different chemical entities present in the natural substrate. It is based on the occurrence of molecular interactions originating from the high complexity of the natural matrix, following the rules of… Read more

    Year

    2014
  • Metabolomics & Analytical Sciences

    Author

    Luisa Mattoli, Michela Burico, Valentino Mercati, Rita Pagiotti, Pietro Traldi, Eugenio Ragazzi

    Title

    Fractal dimension in mass spectra from herbal extracts: Hypothesis for a new method of phytocomplex characterization

    Abstract

    In order to explore new possibilities to optimize the quality control of herbal products, a non-conventional method of analysis of complex systems, the fractal analysis, applied to ElectroSpray Ionisation (ESI) mass spectrometry, was evaluated. The ESI spectra obtained with herbal commercial products were converted into bitmap images and submitted to fractal analysis using the so-called… Read more

    Year

    2013
  • Metabolomics & Analytical Sciences

    Author

    Luisa Mattoli, Michela Burico, Anna Maidecchi, Erika Bianchi, Eugenio Ragazzi, Lisa Bellotto, Roberta Seraglia, Pietro Traldi

    Title

    The fingerprinting of Sedivitax, a commercial botanical dietary supplement: The classical LC-MS approach vs direct metabolite mapping

    Abstract

    The use of phytochemical preparations has shown a massive growth and consequently the related quality control is an important topic. Considering the possible interactions of the active molecules, arising to synergic phe- nomena, the use of the classical approach, based on the evaluation of the level of one or more active compounds can be limitative.Recently a method, based on the direct… Read more

    Year

    2012
  • Metabolomics & Analytical Sciences

    Author

    L.Mattoli, M.Burico, A.Gaetano, R.Seraglia, L.Molin, P.Traldi

    Title

    MALDI mass spectrometry in the characterization of phytochemical products

    Abstract

    Five commercial botanical dietary supplements have been directly analyzed by mass spectrometry by laser irradiation with and without the presence of matrix (in MALDI and LDI conditions). The data so obtained allowed to obtain the characterization of the different samples on the basis of metabolite specific for the different botanic species contained. Furthermore, in the case of positive ion… Read more

    Year

    2012