Scientific Evidence

A comprehensive body of scientific evidence on natural substances developed by Aboca.

  • Biodegradability

    Author

    Luisa Mattoli, Giacomo Proietti, Giada Fodaroni, Claudio Marzio Quintiero, Michela Burico, Mattia Gianni, Emiliano Giovagnoni, Valentino Mercati e Claudio Santi

    Title

    Suspect screening analysis to improve untargeted and targeted UHPLC-qToF approaches: the biodegradability of a proton pump inhibitor medicine and a natural medical device
    DOI https://doi.org/10.1038/s41598-023-49948-8

    Abstract

    Suspect screening and untargeted analysis using UHPLC-qToF are two advanced analytical approaches now used to achieve an extensive chemical profile of samples, which are then typically confirmed through targeted analysis. These techniques can detect a large number of chemical features simultaneously and are currently being introduced into the study of contaminants of emerging concern (… Read more

    Year

    2024
    Products: Neobianacid
    Public Link
  • Clinical Studies

    Author

    Corazziari Enrico Stefano; Gasbarrini Antonio; D'Alba Lucia; D'Ovidio Valeria; Riggio Oliviero; Passaretti Sandro; Annibale Bruno; Cicala Michele; Repici Alessandro; Bassotti Gabrio; Ciacci, Carolina; Di Sabatino Antonio; Neri Matteo; Bragazzi Maria Consiglia; Ribichini Emanuela; Radocchia Giulia; Iovino Paola; Marazzato Massimiliano; Schippa Serena; Badiali Danilo

    Title

    Poliprotect vs Omeprazole in the Relief of Heartburn, Epigastric Pain, and Burning in Patients Without Erosive Esophagitis and Gastroduodenal Lesions: A Randomized, Controlled Trial
    DOI 10.14309/ajg.0000000000002360

    Abstract

    INTRODUCTION: In the treatment of upper GI endoscopy-negative patients with heartburn and epigastric pain or burning, antacids, antireflux agents, and mucosal protective agents are widely used, alone or as add-on treatment, to increase response to proton-pump inhibitors, which are not indicated in infancy and pregnancy and account for significant cost expenditure.

    METHODS: In this… Read more

    Year

    2023
    Products: Neobianacid
    Public Link
  • Real World Evidence

    Author

    R Cioeta, R Cipelli, F Panzieri, D Urbinati, V Idone, A Cossu

    Title

    Real World Clinical Data on the Use of a Natural Molecular Complex for the Treatment of Irritable Bowel Syndrome in Specialist Daily Practice
    DOI https://doi.org/10.1016/j.jval.2022.09.1880

    Abstract

    Aim of this Real World (RW) research was to investigate the effectiveness and safety of the vegetal molecular complex ActiMucin in Irritable Bowel Syndrome (IBS) patients with diarrhea predominant (IBS-D), constipation predominant (IBS-C) and mixed (IBS-M) clinical subtypes.

    Read more

    Year

    2022
    Products: Colilen IBS
    On demand
  • Real World Evidence

    Author

    Roberto Cioeta, Paola Muti, Marta Rigoni, Luigi Morlando, Filippo Siragusa, Andrea Cossu and Emiliano Giovagnoni

    Title

    Effectiveness and tolerability of Poliprotect, a natural mucosal protective agent for gastroesophageal reflux disease and dyspepsia: Surveys from patients, physicians, and pharmacists
    DOI https://doi.org/10.3389/fdsfr.2022.969831

    Abstract

    Background: Gastroesophageal reflux disease (GERD) and functional dyspepsia (FD) are very common in the general population. GERD prevalence is considerably high in pregnant women, and it increases at a young age, alongside obesity. Mucosal protective agents (MPAs) are over-the-counter (OTC) treatments for FD and GERD commonly used alone or as add-on therapy to proton pump… Read more

    Year

    2022
    Products: Neobianacid
    Public Link
  • Clinical Studies

    Author

    Podda Mariangela, Laureti Silvio, Gentilini Lorenzo, Vittori Laura, Poggioli Gilberto

    Title

    Prospective Interventional Study to Evaluate the Effect of a Medical Device Made of Substances in Reducing Signs and Symptoms in Patients with Hemorrhoidal Disease
    DOI 10.36648/2386-5180.9.4.345

    Abstract

    Background and Aim: Hemorrhoidal Disease (HD) is a chronic pathology and is fairly common in the general population. For this reason, conservative therapies need to be at the same time effective and tolerated. The topical medications available usually contain either a combination of local anesthetics with anti-inflammatories or muscle relaxants, thus addressing a single… Read more

    Year

    2021
    Products: Neofitoroid BioOintment
    Public Link
  • Clinical Studies

    Author

    Caterina Strisciuglio, Vincenzo Coppola, Marina Russo, Carlo Tolone, Gian Luigi Marseglia, Alberto Verrotti, Silvia Caimmi, Claudia Caloisi, Valeria D’Argenio, Lucia Sacchetti and Annamaria Staiano

    Title

    Promelaxin Microenemas Are Non-inferior to Oral Polyethylene Glycol for the Treatment of Functional Constipation in Young Children: A Randomized Clinical Trial
    DOI https://doi.org/10.3389/fped.2021.753938

    Abstract

    Background: Polyethylene glycol (PEG) is recommended as first-line treatment of pediatric functional constipation. However, the oral route of administration is often poorly feasible in children mostly due to poor palatability. Promelaxin microenemas exert a topical evacuative action and may offer a valuable option in pediatric FC.
    Aim: To assess whether… Read more

    Year

    2021
    Products: Melilax Pediatric
    Public Link
  • Preclinical Studies

    Author

    Parisio C, Lucarini E, Micheli L, Toti A, Di Cesare Mannelli L, Antonini G, Panizzi E, Maidecchi A, Giovagnoni E, Lucci J, Ghelardini C.

    Title

    Researching New Therapeutic Approaches for Abdominal Visceral Pain Treatment: Preclinical Effects of an Assembled System of Molecules of Vegetal Origin
    DOI https://doi.org/10.3390/nu12010022

    Abstract

    Abdominal pain is a frequent symptom of irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBDs). Although the knowledge of these pathologies is progressing, new therapeutic strategies continue to be investigated. In the present study, the effect of a system of molecules of natural origin (a medical device according to EU Directive 93/42/EC, engineered starting from Boswellia… Read more

    Year

    2019
    Products: Colilen IBS
    Public Link
  • Clinical Studies

    Author

    Marina Russo, Vincenzo Coppola, Eleonora Giannetti, Roberta Buonavolontà, Antonio Piscitelli and Annamaria Staiano

    Title

    Oral administration of tannins and flavonoids in children with acute diarrhea: a pilot, randomized, control-case study
    DOI 10.1186/s13052-018-0497-6

    Abstract

    Background: AG is the most common cause of pediatric consultations among children between 2 and 5 years of age and it still leads to high mortality and morbidity. Its management is based on rehydration therapy, but this treatment is not effective in reducing duration of diarrhea. For this reason, other safer and less expensive interventions, which could be added to oral… Read more

    Year

    2018
    Products: Lenodiar Pediatric
    Public Link
  • Preclinical Studies

    Author

    G. Liguori, F. Baldi, M.P. Di Simone

    Title

    Topical protection of esophageal mucosa: in vitro evaluation of the protective effect of a medical device made of natural substances in comparison with sodium alginate

    Abstract

    OBJECTIVES: The integrity of the esophageal mucosal barrier is the first mechanism of protection against gastro-esophageal reflux. A possible strengthening action of esophageal mucosal barrier could be given by topical agents that act by reducing its permeability. Our aim was to test the protective effect of a medical device made of substances (MDMS), composed by natural complex (… Read more

    Year

    2018
    Products: Neobianacid
    Public Link